Linkage analysis of the 12 alcohol dependence symptoms assessed by the SSAGA was then conducted for the support intervals of the 4 linkage peaks. Both the chromosomes 1 and 2 peaks showed evidence of linkage to a broad range of symptoms from 4 of the 7 DSM-IV symptom clusters. In contrast, the chromosomes 8 and 18 peaks showed evidence of linkage to a much narrower range of symptoms with only 2 DSM-IV symptom clusters represented for each peak. The linked symptoms and the associated LOD scores for each peak are shown in Table 3.
