Sensitivity analyses considering the discovery and replication data of each GWA investigation as separate data yielded largely similar results as the main analysis (Table 2). Minor differences were seen in the exact estimates of I2 but the categorization of the amount of between-study heterogeneity was largely similar. With this analysis, there was now also low heterogeneity (I2<25%) for the HHEX rs5015480-rs1111875 effect, while I2 became 0 for SLC30A8 rs13266634. Again the confidence intervals of I2 were very large, the upper limit being between 61 and 86% for the various markers.
