methods of administration; and the use of healthy individuals, with no regard for sex and age differences. In some circumstances, these weaknesses have led to conflicting and opposing conclusions [102,122]. This is greatly magnified in the contemplation of the use of cannabis or THC-enriched preparations for long-term medicinal use. The long-term use of cannabinoids, notably cannabis or THC-rich products, has significant deleterious effects, especially among humans with addictive liability patterns and can cause serious and permanent harm in adolescents. As mentioned above, between 50% and 95% of heavy users show cannabis withdrawal symptoms [140,141,142,143], with a recent meta-analysis reporting an overall prevalence of 47% among such users [144]. Chronic or heavy cannabis use has been shown to lead to cannabis use disorder (CUD), with strong links to other substance use disorders (SUD) and the symptoms of anhedonia and anxiety that are usually attached to them. In MDD and BD, the conclusions from the meta-analyses were clearly negative regarding the use of cannabis or THC-preparations over the long-term [108]. Although CBD is present in some of these preparations and may inhibit some side effects of THC, there is no certainty that CBD can abolish them all. Furthermore, during the last two
