Nevertheless, the field is still unclear when it comes to recommendations regarding the use of cannabinoids in treating depression, anxiety, and effects of stress, whether as antidepressants or as adjuncts to other antidepressants. Cannabis and its derivatives from both plant-based and synthetic origins are used in many circumstances to treat pain, nausea/vomiting, stress, anxiety and depression co-morbid with serious diseases such as cancer, MS, PTSD, Parkinson’s disease and other illnesses. Although showing a positive effect of cannabinoids in ameliorating the quality of life of many patients, including an improvement in their mood in general, there are many weaknesses and flaws surrounding the studies conducted so far. Different systematic and meta-analysis reviews agree on these aspects and list among the flaws detected: the small sample size of the studies; the lack of RCTs; the use of diverse preparations; different dosages and methods of administration; and the use of healthy individuals, with no regard for sex and age differences. In some circumstances, these weaknesses have led to conflicting and opposing conclusions [102,122]. This is greatly magnified in the contemplation of the use
