Among the 11 RVs genotyped, only one was located in GRIN2B (rs146792012). Compared to the three RVs in DISC1, which were observed in a total of 172 AAs, the minor allele of rs146792012 was found in only three AAs, all OD cases. It was also observed in seven EAs (five OD cases, and two controls). When AAs and EAs were analyzed separately, the association between rs146792012 and OD was statistically significant in AAs only (P=0.00085). When AAs and EAs were analyzed together, the association remained significant, but was weaker (P=0.0031). Despite the significant P value, due to the extremely small MAF, the association between this RV in GRIN2B and OD is not as well supported, compared to the association between DISC1 and OD in AAs.
