Table 2 shows the results among the discovery sub-cohort (N cases=370, N controls=5850) and the replication sub-cohort (N cases=173, N controls=3766), and the entire study population (meta-analysis; N cases=543, N controls=9616). The variants on 6p21.2 showed a consistent signal in the replication analysis (rs7749170 failed in the Sequenom genotyping and is therefore absent), whereas the results for the SNPs on 6p21.32 were diluted or reversed when compared to the GWAS signal. Two out of four of the SNPs on 6p21.2 showed a statistically significant signal in the replication analysis (males and females combined). The most significant signals on 6p21.2 were revealed for rs4714329 (OR=1.75 (1.37–2.24), P=9.0 × 10−6) and for rs9471290 (OR=1.40 (1.09–1.81), P=8.3 × 10−3). The replicating variants were included in a meta-analysis in which rs4714329 yielded an OR of 1.59 (1.37–1.85) and P-value of 1.6 × 10−9, and rs9471290 had an OR of 1.49 (1.28–1.73) and a P-value of 2.9 × 10−7. A post hoc replication analysis of rs4714329 in the female sample (N cases=32, N controls=2179) revealed an OR of 2.55 (1.50–4.33) and a P-value of 5.3
