Since our last publication (6), we have made substantial changes to the infrastructure that improve the GWAS Catalog and ensure sustainability into the future. In parallel we have curated over 600 publications and 10,000 SNP-trait associations since November 2014. We developed a new Catalog infrastructure, launched in March 2015 with a redesigned database, improved data model, curation interface, user interface and download files. In addition, the new website (www.ebi.ac.uk/gwas/) has ontology supported search functionality and an interactive search results interface. All software for the Catalog's infrastructure is open source and made available via a public GitHub repository (https://github.com/EBISPOT/goci) using an Apache 2.0 licence. All Catalog data are freely and publicly available facilitating integration with bioinformatics resources.