GWAS study design has evolved and complexity has increased since the inception of the Catalog, rendering it more challenging to understand and represent the study design, and to extract greater volumes of data. Specifically, there has been significant growth in the number of publications describing multiple GWAS, SNP-by-SNP and SNP-by-environment interaction studies, and in the number of traits and ancestry categories analyzed per publication (Figure 2), along with an average 50% increase in eligible SNP-trait associations year on year over the last 4 years.
