work in the same pathway in regulating neuronal development. While it remains an intriguing hypothesis that defects in adult hippocampal neurogenesis may contribute to psychiatric disorders (Ming and Song, 2009), the signaling mechanism identified here provides an important framework to understand how multiple susceptibility genes functionally converge onto a common pathway that may underlie the etiology of psychiatric disorders. Future characterization of a core molecular pathway with a focus on DISC1 and other schizophrenia susceptibility genes may lead to a profound advance in understanding schizophrenia and the development of therapeutic interventions.
