Significant sQTLs show a high degree of sharing among tissue pairs, with tissue-specific sQTLs accounting only for 7 to 21% of the total depending on the tissue (figs. S27 and S28). The highest degree of sharing is between heart left ventricle and whole blood, whereas the two tissues that share the fewest sQTLs are whole blood and Sun-exposed skin. In general, sQTLs identified in whole blood are shared at lower levels with other tissues, as was observed for eQTLs (Fig. 2A and fig. S12, A and B). Although we observe the same enrichment of sQTLs around the TSS as seen for eQTLs, the sQTLs that are shared across multiple tissues tend to be closer to the TSS than those that are tissue-specific (fig. S28). On average, 20% of sQTLs associated with changes in exon junction abundance by Altrans were also predicted to be eQTLs (π1 = 0.20, π1 = 0.14 to 0.27; table S10). An even larger fraction (48%) of sQTLs detected by sQTLseekeR associated with changes in relative abundances of gene transcript isoforms, were identified as eQTLs (π1 =
