Two type 2 diabetes (T2D) GWA studies were analyzed in this work. The first is the Diabetes Genetics Initiative (DGI) GWA study, used for method development purposes. 381,099 genotyped SNPs were analyzed using only the population-based individuals, that consist of 1,022 diabetic patients and 1,075 matched control individuals (a total of 2,097 individuals) [17]. The second study is the most recent T2D GWA meta-analysis (DIAGRAM+) [36], used to test the mitochondrial-diabetes hypothesis with MAGENTA. The meta-analysis was performed across eight GWA studies, with a total of 8,130 diabetic patients and 38,987 non-diabetic controls (47,117 individuals total, effective sample size n = 22,044), and 2,255,856 genotyped and imputed autosomal SNPs.
