We used the Million Veteran Program (MVP) (45,46) datasets as discovery samples and examined EA and AA PRSs for ICD 9/10 AUD, Alcohol Use Disorders Identification Test-Concise (AUDIT-C) scores, and MAX_ALC, defined as the highest number of drinks a subject reported drinking during a single day in a typical month (46). The MVP dataset included AUD cases (56,000, including 34,000 EA and 17,000 AA) and controls (219,000, including 167,000 EA and 39,000 AA). This is the largest sample of AUD cases available currently (although there are larger samples with data on consumption or problematic use). Variants located within 500 kb of the index variant and having R2 > 0.25 with the index variant were clumped. PRSs were calculated as the sum of allele counts weighted by the sign of the log odds ratio and the negative log-transformed p value for each SNP. The weighting by p value was used because it is robust to variations in sample size from SNP to SNP. Each PRS was tested at nine thresholds. A p value of 3.3 × 10−4 was considered significant for
