patterning of specific brain structures during development, such as the cortex or amygdala (Bulchand et al., 2003; Remedios et al., 2004), through its ability to regulate transcription. Subtle changes in patterning during development might later affect behavioral responses to ethanol in adults. Little is known regarding the molecular mechanism of LMO3 function or its transcriptional targets, although binding partners of LMO3 include the neuronal transcription factor HEN2 (Aoyama et al., 2005), p53 (Larsen et al., 2010), and the calcium and integrin binding protein, CIB (Hui et al., 2009). In the adult animal, Lmo3 expression is increased by seizure activity in the hippocampus (Hinks et al., 1997). Lmo3 expression is also increased by dopamine treatment of glial cell cultures (Shi et al., 2001). The mechanism of LMO3 function in behavioral responses to ethanol has not been studied. It is tempting to speculate that Lmo3 expression/and or function is regulated by ethanol in the adult brain, and that Lmo3 in turn modulates behavioral responses to ethanol in the adult animal. As an attempt to address this possibility, we examined Lmo3 expression in response to ethanol in the cortex, striatum, hippocampus, cerebellum, and olfactory bulb by qPCR, and observed no significant changes following
