Ratings on the POMS subscale of depression/negative affect were higher after 5 days of abstinence. The FAAH C/A carriers (Fig. 2) trended toward a significant abstinence × genotype interaction, F(2,194) = 3.31, P < 0.056, while CNR1 T/C carriers (Fig. 3) demonstrated a significant abstinence × genotype interaction, F(2,194) = 5.22, P < 0.02. However, exposure to a marijuana cue had no effect. Furthermore, there was a significant additive interaction effect of these two genotypes on negative affect such that individuals that were FAAH C/A carriers and CNR1 T/C carriers reported greater negative affect than any other genotype combination F(2,194) = 3.55, P < 0.047 (Fig. 4).
