Another avenue where PRS may be useful in clinical practice in psychiatry is in the prediction of risk of commonly comorbid general health conditions, which impact treatment options and treatment adherence, as well as long-term health outcomes for people with psychiatric illness. For instance, a depression PRS has been associated with higher risk of ischemic stroke, such that stroke risk increased by 3.0% for every one-standard-deviation increase in PRS for those of European ancestry and by 8% for those of African ancestry 53.
