Increasing discovery sample sizes and ethnic diversity for GWAS, potentially leveraging large populations represented in national biobanks and disease consortia, will improve the prediction models for PRS considerably, including improvements in both the positive and negative predictive value 22, 42. Other methodological changes in PRS calculation, particularly machine learning approaches which may simultaneously examine both clinical and genetic heterogeneity 54, may be expected to have an impact on predictive power as well. Thus, although PRSs are not routinely used in clinical practice in psychiatry at this time, the great advances afforded by current genomics research may reveal avenues for personalized medicine which will drastically change the way that psychiatric disorders are treated clinically in the years to come.
