Chunk #79 — Results and discussion — NIA-AA biomarker analysis in specific brain regions of 3xTg-AD mice (1-month post alcohol) — Prefrontal cortex (PFC)
Alcohol intake significantly increased the Aβ (42/40) ratio [t(7) = 2.2, P = 0.03], but had no effect on Tau expression (Fig. 6B). Elevated Aβ42/40 ratio in the PFC is indicative of Alzheimer’s pathologic change (e.g., A + T − (N)−) as reflected by amyloid pathology (Table 2), which is thought to occur at a (moderate) stage of AD (Braak & Braak, 1998); thus, alcohol drinking appears to enhance the onset of PFC-linked AD pathology in 3xTg-AD mice.
