Chunk #80 — Results and discussion — NIA-AA biomarker analysis in specific brain regions of 3xTg-AD mice (1-month post alcohol) — Medial prefrontal cortex (mPFC) and amygdala (AMY)
Alcohol had no effect on the Aβ (42/40) ratio in the mPFC or AMY. However alcohol drinking was associated with an increase in total Tau expression in both brain regions: mPFC—[t(7) = 3.0, P = 0.02] (Fig. 6C); AMY—[t(7) = 3.6, P = 0.009] (Fig. 6D). This result is consistent with non-AD pathologic change (e.g., A − T − (N)+, Table 2); however, Tau-related pathology is associated with late-stage AD suggesting that alcohol may exacerbate the onset of pathology in the AMY.
