of genes on listP-valueStudy-wide P-valueE hits/studySignalling events mediated by focal adhesion kinase7056747.11<10−40.0880.13Trail signalling pathway7159147.01<10−40.0880.13p53 pathway221609.24<10−40.0880.13Signalling events mediated by the hedgehog family13514.78<10−40.0880.13Class I PI3K signalling events6654443.8710−40.12850.19Syndecan-1-mediated signalling events7259749.572.0 × 10−40.170.26Glypican pathway9280868.24.0 × 10−40.24650.42Hedgehog signalling pathway (KEGG)11543.685.0 × 10−40.27950.51Signalling events mediated by hepatocyte growth factor receptor (c-Met)7158549.136.0 × 10−40.31350.59Class I PI3K signalling events mediated by AKT5445735.997.0 × 10−40.34850.66Glypican 1 network7968557.338.0 × 10−40.38450.76Endothelins4936433.30.00110.46651.03EGF receptor (ErbB1) signalling pathway7969759.010.00190.65651.8Internalization of ErbB17969759.010.00190.65651.8ErbB1 downstream signalling7969759.010.00190.65651.8Integrins in angiogenesis13635.70.0020.6711.89Prostate cancer (KEGG)14796.40.0020.6711.89Downstream signalling in naïve CD8+ T cells9423.870.00270.7582.541 and 2 methylninaphthalene degradation (KEGG)370.310.00270.7582.54Immunoregulatory interactions between A lymphoid and a non-lymphoid cell6341.590.0030.78752.81Results of top 20 pathways from the ALIGATOR analyses of the ‘age at first tooth’ GWAS. P-value threshold of 0.005. There were 1358 genes significant at this threshold from a total of 19 887 genes included in our analysis. All pathways presented are from the NCI pathway interaction database unless stated.
