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Chunk #32 — Discussion

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Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children.
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lifestyle [33]. On the contrary, a recent study suggests that those shown to be genetically susceptible to obesity may even worsen their dietary habits [33]. Convincing evidence of gene–lifestyle interactions, however, might give people a sense of control that risk-reducing behaviors can be effective in prevention. Thus, identifying interactions between genes and lifestyle is important as it demonstrates that a genetic susceptibility to obesity is modifiable by lifestyle. Furthermore, insights from gene–lifestyle interactions contribute to elucidating the mechanisms behind genetic regulation of obesity, which may help in the development of new treatments in the future.