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Chunk #23 — GABRG1 haplotype associations — Finnish Caucasians

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GABRG1 and GABRA2 as independent predictors for alcoholism in two populations.
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There were 13 long-distance haplotypes with ≥ 0.01 frequency that accounted for 0.89 of the haplotype diversity. Of these, five haplotypes had a frequency of ≥ 0.05 (H1: 0.30; H2: 0.07; H3: 0.11; H4: 0.16, H5: 0.07), accounting for 0.71 of the haplotype diversity in the total sample. For simplicity, analyses were conducted with the haplotypes ≥ 0.05 frequency. Analyses undertaken with these five haplotypes showed that H1 was more abundant in alcoholics, H3 – H5 were more common in non-alcoholics and H2 was neutral: H1 vs rest: χ2 = 7.3, 1 df, p = 0.007 (Figure 5).