Figure 5 illustrates the relative contributions from GABRG1 and GABRA2 haplotypes to the extended haplotypes’ association with AUD. H1: both the GABRG1 block 1 and block 2 haplotypes are increased in alcoholics, therefore extended haplotype H1 is increased in alcoholics. H2: the GABRG1 block 2 haplotype is increased in alcoholics, the block 1 haplotype is decreased in alcoholics therefore extended haplotype H2 is neutral to AUD diagnosis. Haplotypes H3 and H4 are less abundant in alcoholics: in both cases the GABRG1 block 1 and block 2 haplotypes are decreased in alcoholics. Haplotype H5 is numerically increased in non-alcoholics: the GABRG1 block 2 haplotype is neutral; the block 1 haplotype is more common in non-alcoholics. As discussed above, GABRA2 haplotypes were not associated with AUD and, as seen in Figure 5, did not contribute to the extended haplotypes’ association with AUD.
