A subset of the Stage II families was selected for an initial and a replication genome survey using microsatellite markers. These pedigrees were pruned to eliminate uninformative individuals and branches from the genotyped sample. The initial sample (Wave 1) included 105 multigenerational pedigrees that include 1,214 members, of whom 983 individuals were genotyped. The replication dataset (Wave 2) included 157 multigenerational pedigrees (1,295 individuals).
