Table 3 shows associations between conduct problem trajectories and cannabis use at 16. Risk of both any use of cannabis and of problem cannabis use is elevated among children with conduct problems. The effect on any cannabis use is generally small and estimated imprecisely, with the exception of the association between adolescent-onset conduct problems and any cannabis use. For all conduct problem categories the effect on problem cannabis use is greater than that on any cannabis use. This is particularly evident in relation to early-onset persistent conduct problems that are associated with a greater than sixfold increased risk of problem cannabis use. These associations are attenuated after adjustment for earlier life factors preceding conduct problems, although in the case of early-onset persistent conduct problems and problem cannabis use the effect remains strong and substantial.