with both any use and problem use of cannabis by their offspring at age 16. The largest effect was seen with maternal cannabis use. For maternal cannabis use and maternal tobacco use the effect appeared greater on risk of problem cannabis use, whereas with maternal alcohol use the stronger and more substantial effect was on any use of cannabis. Risk of any cannabis use was higher among girls compared to boys, whereas the opposite was true for risk of problem cannabis use. Adjustment for conduct problem trajectory attenuated these associations although, in general, they remained strong and substantial.
