Chunk #25 — Results — BK mRNA splice variants encode channels with varied alcohol responsiveness

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Posttranscriptional regulation of BK channel splice variant stability by miR-9 underlies neuroadaptation to alcohol.

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To determine whether reorganization of BK transcript profile can contribute to the development of alcohol tolerance we used heterologous expression to measure alcohol’s effect on activity of individual BK splice variants: INSERTLESS, ALCOREX and STREX.