The meta-analysis across discovery cohorts was run for the pooled male-female GWAS results (N=16,400), as well as separately for the sexes (females, N=8535; males, N=7772), using a fixed-effects model with z-scores weighted by sample size as implemented in the software METAL(Willer, Li, & Abecasis, 2010). We only reported and interpreted the results of polymorphisms with a total sample size greater than 10,000 (across all samples) and 5000 (sex-specific). The genome-wide significance threshold was set at 1.67 x 10-8 as we performed three meta-analyses and polymorphisms with p-values < 10-6 were considered suggestive findings.
