We performed a polygenic risk score (PRS) analysis in the Finnish Crime Study to test whether a genetic risk for ASB could significantly discriminate between prisoners and matched controls. We used the software package PRSice to estimate the best-fit PRS at a broad range of p-value thresholds. For clumping, the LD threshold was set to an r2 of .25 and 500 kb distance. PRS analyses were conducted based on the sex-combined samples and the male-specific samples (given the overrepresentation of male prisoners) and sex, age, and four principal components were included as covariates. In addition, to evaluate evidence for shared genetic etiology, we employed the summary-summary statistic based analysis as implemented in PRSice, using the sex-combined, male-specific and female-specific samples in MSUTR and Yale-Penn, after applying more stringent clumping thresholds (r2=.05, 300 kb distance).
