The effects of lung cancer sentinel variants and smoking behavior were assessed based on the meta-analysis across 3 studies: ever-smoking controls with intensity information from the Oncoarray studies (N=8,120), deCODE (N=40,882) and UK Biobank (N=42,044). The association with nicotine dependence was evaluated based on Fagerstrӧm Test for Nicotine Dependence (FTND) data collected in 4 studies (n=17,074): deCODE Genetics, Environment and Genetics in Lung Cancer Etiology (EAGLE), Collaborative Genetic Study of Nicotine Dependence (COGEND), and Study of Addiction: Genetics and Environment (SAGE) and among current smokers in one other study [Chronic Obstructive Pulmonary Disease Gene (COPDGene). The study-specific SNP association results were combined using fixed effects, inverse variance-weighted meta-analysis with genomic control applied. Specifically, for the 8p21 variant rs11780471, we additionally considered other aspects of smoking behavior data from UKBiobank, deCODE and OncoArray controls. We additionally included summary statistics for the rs11780471 variants from the TAG consortium (described in detail in the Supplementary Note).
