Consistent with previous findings (27, 28), the main effects of task analyses revealed robust amygdala reactivity (Figure 1, panel A). Regression analyses predicting threat-related amygdala reactivity in the entire sample produced a significant overall model for reactivity of the right but not the left amygdala (right: F=4.13, df=5, 273, p=0.001, R2=0.07; left: F=0.95, df=5, 273, p=0.45, R2=0.02). In the right amygdala, greater childhood emotional neglect (b=0.06, SE=0.02, t=3.02, p=0.003; Figure 1B) and val carrier status (b=0.31, SE=0.15, t=2.06, p=0.04; Figure 1C) independently predicted heightened threat-related amygdala reactivity. The interaction of mineralocorticoid receptor genotype and childhood emotional neglect contributed significantly to the model after accounting for these main effects (b=−0.10, SE=0.05, t=−2.06, ΔF=4.26, ΔR2=0.014, p=0.04, not controlling for main effects of genotype or emotional neglect; b=−0.14, SE=0.05, t=−2.92, ΔF=8.51, ΔR2=0.03, p=0.004). As shown in Figure 1D, simple slope analyses indicated a significant positive association between childhood emotional neglect and threat-related amygdala reactivity in iso homozygotes (b=0.08, SE=0.02, t=3.64, p=0.0003) but not in val carriers. Moreover, Johnson-Neyman analyses revealed that iso homozygotes had reduced amygdala reactivity relative to val carriers at low
