significant positive association between childhood emotional neglect and threat-related amygdala reactivity in iso homozygotes (b=0.08, SE=0.02, t=3.64, p=0.0003) but not in val carriers. Moreover, Johnson-Neyman analyses revealed that iso homozygotes had reduced amygdala reactivity relative to val carriers at low emotional neglect scores (i.e., participants at or below the 60.2 percentile; those scoring 8 or lower on the Childhood Trauma Questionnaire emotional neglect scale; t>1.97 and p<0.05 in all cases). When ancestry-informative principal components were added to the first step of the regression or when the same analyses were conducted for Caucasians only, the main findings were reproduced, except that the main effect of mineralocorticoid receptor genotype was reduced to a trend in analyses with principal components (see the online data supplement). Exploratory analyses using the other Childhood Trauma Questionnaire subscales (emotional abuse, physical neglect, physical abuse, and sexual abuse) revealed no significant overall models (F<1.92 and p>0.09 in all cases).
