A similar pattern of results was found when rimonabant was infused ventral to the hippocampus. Systemic administration of Δ9-THC impaired choice accuracy (main effect of Δ9-THC, F (1,11) = 162.88, p < 0.0001; Figure 4A) and slowed running speed (main effect of Δ9-THC, F (1,11) = 6.27, p < 0.05; Figure 4B). Microinfusion of rimonabant below the hippocampus did not modify the disruptive effects Δ9-THC on either choice accuracy (main effect of rimonabant; p = 0.09; interaction between rimonabant and Δ9-THC: p = 0.45) or radial arm entry rate (main effect of rimonabant; p = 0.06; interaction between rimonabant and Δ9-THC: p = 0.08). Cannulae placements are shown in Figure 4C.
