As with all studies, the current results must be considered in the context of the methods used. First, the subjects in the SDPS are almost all of EA descent and most offspring come from families with relatively highly educated parents, raising the question of whether the results are likely to generalize to less educated subjects. However, support for the current findings regarding SRE-5 comes from two COGA- based papers reporting data across two generations of what are generally lower educated and lower socioeconomic families (Schuckit et al., 2001, 2005). Second, all correlations reported here are cross sectional and it will be important to evaluate similar hypotheses in a prospective model. Third, a caveat inherent in all measures of LR is that this characteristic can only be evaluated in individuals who have had experience with alcohol. Fourth, the distinction between the aspects of drinking reaction related to SRE-5 versus SRE-T (i.e., more sensitivity for the former but both sensitivity and intersession tolerance for the latter) are hypothetical and difficult to prove. Fifth, it is important to remember that a person’s response
