the expression of GRIN2B and GRIN2D returned to baseline levels (F(1,43)=0.2, p=0.64, and F(1,40)=0.6, p=0.44, respectively). In contrast, following 7-day alcohol exposure of neural cultures derived from non-alcohol dependent subjects there was no change in the expression of the four NMDA subunit genes (GRIN1 F(1,29)=1.0, p=0.32, GRIN2A F(1,25)=0.06, p=0.82, GRIN2B F(1,29)=0.75, p=0.39, GRIN2D F(1,27)=0.26, p=0.62). Withdrawal effects on mRNA concentration were available for only 2 of 3 cultures derived from non-alcoholics, precluding a meaningful analysis of that condition.
