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Chunk #30 — Results — Effect of Repeated Alcohol Exposure on NMDA Subunit mRNA Expression

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Pilot study of iPS-derived neural cells to examine biologic effects of alcohol on human neurons in vitro.
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Subject-to-subject differences in responses were noted (Fig. 5 A–D), with a greater proportion of alcoholic subjects (4 out of 4) showing at least a 50% increase in expression for one or more NMDA receptor subunits compared to non-alcoholics (1 of 3) after a 7-day exposure.