Offspring from high-risk families had an overall higher level of exposure to alcohol than did low-risk controls. Risk group differences were also seen for use of cigarettes and for number of days during pregnancy in which drugs were used (Table 1). Drug assessment included questions concerning specific use of opioids, cocaine, hallucinogens, and cannabis. The predominant drug use reported was for cannabis. Additionally, differences in alcohol use were seen in the risk by time interaction across trimesters due to larger differences in exposure in the first trimester (F= 4.11, df=2,77, p=0.020).
