In the first whole brain VBM analysis of the 88 subjects, complete covariate information was available for 75 subjects (36 HR and 39 LR) that included gender, intracranial volume (ICV), and personal history of SUD and prenatal exposure to alcohol, cigarettes, and drugs. Data were thresholded at p<0.005 and 200 voxels. This analysis revealed gray matter volume differences in the left fusiform, left insula, right lingual area and in cerebellum, lobes 8 and 9 (left) that survived FWE correction (Figure 1). These results were supported by analyses using SPSS (Table 2).
