Bcl-2 and Bcl-XL are antiapoptotic members of the Bcl-2 family and can protect against certain models of cell/tissue injury, including alcohol toxicity [35,36]. Levels of Bcl-2 were lowered by about 50% in the ethanol-fed KI mice (Fig 6A,6B). Levels of Bcl-XL were significantly lowered about 40% by ethanol in livers of WT mice and by 30 % in the KI mice (Fig. 6B,6C). Ethanol had no effect on the levels of Bcl-2 and Bcl-XL in the KO mice.
