The master regulator of lipogenesis SREBP, was shown to be elevated by ethanol in some models e.g. low fat intake with a subsequent increase in lipogenic enzymes such as acetylCoA carboxylase [37–41]. A master regulator of lipolysis, PPARα, was shown to be decreased by ethanol in those models, with a subsequent decrease in lipolytic enzymes such as acyl CoA oxidase [37–41]. Such changes play a key role in the overall mechanism by which ethanol induces a fatty liver. We did not observe any changes in levels of SREBP or ACC by ethanol in any of the groups of mice (data not shown). Levels of SCD-1 were increased by ethanol in all the groups of mice, although the levels were lower in both the dextrose and ethanol fed KO mice (Fig. 7A). Levels of PPARα were decreased by ethanol in both the WT and the KI mice, but ethanol had no effect on PPARα levels in the KO mice (Fig. 7B). A downstream target of PPARα, peroxisomal acyl CoA oxidase, responded in a similar manner, being decreased by ethanol in WT
