paperKB
coga / coga-kb
Help
Sign in

Chunk #36 — Discussion

Source
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children.
Embedded
yes

Text

In studies with continuous measures of PA, we chose to use a definition of “inactivity” based on a relative (lowest 20%) cut-off of PA levels. The use of a cut-off based on fixed percentage may have introduced heterogeneity as the percentage may correspond to different absolute PA values in the participating studies. However, the use of an absolute cut-off might have led to even greater heterogeneity, because of the wide differences in the measurement instruments that were used to provide the continuous measures of PA. In theory, the accuracy of a relative PA cut-off could be improved by choosing a specific cut-off for each country on the basis of national PA data. In practice, however, comparing PA data between countries is difficult, as prevalence estimates for sedentariness have been assessed by different survey instruments, which sometimes have also changed over time, and prevalence estimates are not always available from representative samples of the population.