Table 1 presents lead SNPs from the ALCP-total GWAS across the three GWAS. In the ALCP-total GWAS, we identified 542 genome-wide significant (p < 5 × 10–8) SNPs before pruning for LD. Table 1 includes the 11 independent (LD threshold of r2 < 0.1) lead SNPs for ALCP-total, and their corresponding estimates in the EXT and ALCP-specific GWAS results. Of these, only the locus on chromosome 3 (rs10511087), in the CADM2 region, was significant in the EXT GWAS, and the large number of SNPs before pruning were likely the result of a long-range LD region near CADM2. The lead SNP from another locus, located on chromosome 11, was in LD with one of the top SNPs from the EXT GWAS in NCAM1 (rs9919558, p < 6.50 × 10–59). Notably, none of the SNPs on chromosome 4 were significant (or in LD) in the EXT GWAS. Instead, 8 of the 9 lead SNPs on chromosome 4 were significant in the ALCP-specific GWAS. The top SNPs for ALCP-specific are in ADH1B and ADH1C, which are involved in alcohol metabolism, as well as
