LD) in the EXT GWAS. Instead, 8 of the 9 lead SNPs on chromosome 4 were significant in the ALCP-specific GWAS. The top SNPs for ALCP-specific are in ADH1B and ADH1C, which are involved in alcohol metabolism, as well as other genes previously associated with alcohol phenotypes including KLB [30].Table 1ALCP-total Lead SNPs across ALCP-total, EXT, and ALCP-specific GWASs.ALCP-totalEXTALCP-specificSNPCHRBPNearest GeneDir−log10(P)Dir−log10(P)Dir−log10(P)rs10511087385439136CADM2+8.41+48.15+3.26rs6842066439393801RNU6-887P−9.49+0.94−10.08rs28712821439413780KLB−11.04+0.81−11.61rs12299844100239319ADH1B−46.19+1.66−48.27rs38118024100244221ADH1B−14.19+1.06−14.98rs31140454100252560ADH1C−7.88+0.67−8.30rs46997434100282103ADH1C+8.29−0.57+8.67rs1114660944100408974RP11-696N14.3+8.15−2.06+9.13rs131350924103198082SLC39A8+14.51+1.72+13.23rs343331634103283117SLC39A8+7.51+1.37+6.72rs3527707311113350620DRD2+7.49+2.47+6.40Independent lead SNPS from ALCP-total GWAS pruned for an LD threshold of r2 < 0.1.Bolded = genome-wide significant (p < 5 × 10−8).
