Gene-based analyses identified 13 genes associated with ALCP-total, but only 2 genes associated with ALCP-specific. Analysis of tissue expression in MAGMA and H-MAGMA did not allow for comparisons because of the limited power in the ALCP-specific results. In S-PrediXcan, only ADH1C was significantly associated with ALCP-specific. While these results do not point to any new biological pathways of risk, the biological sources of genetic variance across these different pathways reaffirm that EXT is capturing a broader risk domain, while ALCP-specific is identifying genes primarily associated with the pharmacokinetics of alcohol (see Supplementary Tables 8–11 for full results).
