ALCP-total was significantly correlated with 64 of the 99 preregistered phenotypes. We focus on the 35 traits related to substance use, personality, and other psychiatric outcomes (full results in Supplementary Table 2). Figure 2 provides two depictions of the results. Panel A presents the (rg) estimates (and 95% confidence intervals) between ALCP-total (yellow), ALCP-specific (teal), and the other traits. Here, the asterisks denote genetic correlations that differ significantly from ALCP-total to ALCP-specific. Three of the genetic correlations for substance related phenotypes (drug exposure, maternal smoking, and age of smoking initiation) and four genetic correlations for psychiatric traits (stress-related disorders, manic symptoms, psychotic symptoms, and iPSYCH cross-disorder) differed across the two sets of GWAS. None of the estimates for the personality related traits differed significantly across the sets of results.
