Interpretation of neuroimaging data obtained from patients and controls during tests of risk-related decision-making is a significant challenge as broad neural networks are involved and the designs of some tasks limit their implementation in event-related fMRI analysis. However, animal models offer the opportunity for controlled investigation of relevant circuitry. For a more detailed review of the neural circuitry implicated in specific components of risk-related decision-making in addiction, see Diekof, Falkai & Gruber.243 Below we outline recent human and rodent data that implicates a frontal-striatal network in regulation of behavior in these tasks; these results are presented graphically in Figure 1.
