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Chunk #66 — BRAIN STIMULATION TECHNIQUES AND NETWORK ANALYSIS IN NEUROPSYCHIATRIC DISEASE — Schizophrenia

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Exploration and modulation of brain network interactions with noninvasive brain stimulation in combination with neuroimaging.
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Functional connectivity abnormalities in schizophrenia have received even more attention than depression, but with the result of even greater heterogeneity in the reported abnormalities (Greicius, 2008; Fox & Greicius, 2010; Zhang & Raichle, 2010). Reported functional connectivity abnormalities include decreased correlations between the left temporoparietal junction and the right homotope of Broca, decreased or increased correlations within the DMN, and decreased, increased or unchanged correlations and anticorrelations between the DMN and other systems (Liu et al., 2006, 2008; Liang et al., 2006; Salvador et al., 2007; Zhou et al., 2007; Bluhm et al., 2007, 2009b; Jafri et al., 2008; Whitfield-Gabrieli et al., 2009; Vercammen et al., 2010a). Decreased correlations between activity in the posterior cingulate cortex and the rest of the DMN have been related to the severity of positive symptoms (Bluhm et al., 2007), while reduced coupling between the left temporoparietal junction and the bilateral anterior cingulate as well as the bilateral amygdala was associated with worse auditory hallucinations (Vercammen et al., 2010a). With regards to the underlying cerebral pathology, the most consistent abnormalities have been noted in the