in depression was significantly correlated with the rTMS-induced blood flow changes. Thus, these studies all demonstrated that prefrontal rTMS modulates the activity of a widespread network involving regions known from prior functional connectivity studies to be involved in depression. These studies also suggest that rTMS0 may exert its effects via a normalization of abnormal network activity. Approaches combining noninvasive brain stimulation with neurophysiologic and neuroimaging functional network analysis promise to enable more individually-tailored stimulation protocols that may enhance the efficacy of rTMS.
