“e-CN-magenta”, “e-VS-pink”, and “e-PUT-black” revealed the signal transducer and activator of transcription 3 (STAT3) gene as a conserved hub node in all three brain regions (Fig. 2D–F). There was also a wide overlap of the genes in the three modules: 174 (22.54%) were partially shared between all three modules corresponding to the three brain regions, while another 21.76% were shared between at least two modules (Fig. 2B). A gene network analysis of the 174 shared genes between regions identified STAT3, TP53, ICAM1, MYC, and NFKBIA as the top 5 hub nodes of the network. A visualization of the network is depicted in Fig. 3.
