In the CN, WGCNA resulted in 36 modules with a median size of 346 CpG-sites (range: 66–41,423). Module “m-CN-red”, consisting of 2117 CpG-sites, showed the strongest association with AUD case control status (r = −0.27, p = 0.021). This module was most highly enriched for the biological processes “cell activation” (p = 1.52 × 10−5) and “leukocyte activation” (p = 2.09 × 10−5). In PUT 177 modules were identified (median size = 57 CpG-sites, range: 30–42,248). Module “m-PUT-plum” consisted of 70 CpG-sites and was significantly associated with AUD case/control status (r = −0.29, p = 0.023) and enriched for the biological processes “positive regulation of I-κB kinase/NF-κB signaling” (p = 0.002) and “regulation of I-κB kinase/NF-κB signaling” (p = 0.005). WGCNA in the VS methylation data resulted in 85 modules (median size = 178 CpG-sites, range: 35–30,370). The module with the strongest association with AUD was “m-VS-lavender” (r = −0.29, p = 0.023), which consisted of 117 CpG-sites and was enriched for the molecular function “natural killer cell lectin-like receptor binding” (p = 3.43 × 10−4) and the biological process
