Chunk #9 — MATERIALS AND METHODS — Generalization

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Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans.

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Using the NHGRI GWAS catalog, we identified SNPs associated with PR interval, QTc interval, QRS duration, and heart rate at significance threshold of p<10−6 from European or Asian -descent populations. We then examined the significance level and direction of effect for the same SNP-trait pair in this African American dataset.